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Synthesis and characterization of a bifunctional platform based on magnetite-gold nanoparticles for theranostics of cancer
* 1 , * 2
1  PhD Student, Department of Enzymology, Laboratory of Biomedical Nanomaterials
2  Student of the Department of Physical Materials Science, Laboratory of Biomedical Nanomaterials
Academic Editor: Antonio Di Bartolomeo


One of the most interesting objects in terms of use in biomedicine are the hybrid structures based on magnetic nanoparticles (NPs) and NPs of noble metals which make it possible to simultaneously introduce two types of ligands onto the surface of NPs for their further use for photodynamic cancer therapy (PDT) (a combination of a photosensitizer (PS) for therapy and a fluorophore (FP) for platform detection). Synthesis and the research NPs Fe3O4-Au with "dumbell" structure as the bifunctional platform for therapy of oncological diseases was the purpose of this work. As a result of iron pentacarbonyl decomposition in diphenyl ethers in the presence of tetrachlorurates of hydrogen hybrid NPs of magnetite and gold with a size of Fe3O4 10,8 ± 1.5 nanometers and Au 4.4 ± 0.8 nanometers (according to the TEM) stabilized by oleic acid are synthesized. By results of the X-ray phase analysis the synthesized NPs have crystal structure like "spinel" with the period of a lattice of 0.8387 nanometers. By results of measurement of the NPs magnetic properties had magnetization of saturation of 62 Am2 · kg (Fe3O4)-1 and coercive force 13 E. NPs modified 3.4-dihydroxyphenylacetic acid (DOPAC) for the subsequent covering the stabilizing polyethyleneglycol (PEG) by a carbodiimide method. As in one system it is necessary to unite two different substances (PS and FP), as "link" Fe3O4-Au NPs (stabilized) were used. When studying the optical properties of the synthesized platform Fe3O4-Au/PS/FP, the emission and absorption peaks of PS and FP were identical to the peaks of PS and FP in solution. Also analyses of NMR and IR spectroscopy confirmed structure of a system. Further is going to calculate physical and chemical parameters of the synthesized system for optimization and therapy of in vitro and in vivo.

Keywords: nanomaterials, targeted therapy, magnetite, PDT, photosensitizer, fluorophore, FRET, theranostics