Nanotechnology is used today in a wide range of industries. Weakly water-soluble medications are better soluble and bioavailable when delivered by nano-specific drug delivery methods, such as nanocrystals. Another name for ziprasidone is (5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one. A brand-new "atypical" or "second-generation" antipsychotic drug. Its multipotent G-protein-coupled (GPCR) receptor binding profile is distinctive. It is used to treat bipolar disorder-related acute manic or mixed episodes as well as schizophrenia. Schizophrenia is a serious mental condition in which a person experiences bizarre reality views. Ziprasidone is a highly lipophilic and unstable drug. Another incarnation of ziprasidone nanoparticles is used to treat diseases. When ziprasidone is present in the form of particles with an effective average crystal size of less than or equal to 100 nm, the term "nanoparticle" is frequently used to characterize them. A colloidal submicron dispersion of ziprasidone particles is what ziprasidone nano suspension and nano emulsion are made of. One formulation that makes use of solubilization technology is a nanosuspension of crystalline ziprasidone free base. In order to get around the drug's solubility issue and investigate its potential for nose to brain delivery, the buffered nano emulsion of ziprasidone HCl has also been created. We discussed numerous ziprasidone nano formulations used to treat psychotic illnesses in this review.