The gene HOXD13 is a member of the homeobox gene family. The homeobox genes encode a
highly conserved family of transcription factors involved in morphogenesis in all multicellular
organisms.HOXD13 is the first HOX gene known to be linked to human developmental disorders. Mutations
in HOXD13 are associated with limb deformities in both humans and mice, suggesting a critical
role in limb development.The methodology for the project is started by comparing our reference sequence which is of homo
sapiens and the name of our gene is HOXD13 with an excession id-3239 with all the other 14
sequences of different species. This query gene is present on chromosome number 2 and the locus
is NC_000002 and its length is equal to 8458bp.Observation-based study of the Evolution
of HOXD13 gene in 16 different species via Phylogenetic Analysis using MEGA-X andother Bioinformatics Tools.The methods we use is phylogenetics analysis (Mega X)Due to the mutagenesis occurring at various speciation events, the 16 different species have been divided into various groups and subgroups. Based on the amount of conserved sequence that they have inherited, the species are classified as closely linked and distantly linked. For the samereasons, outgroups are also produced. Thus, it can be seen that the mutations occurring in a singular
gene can produce such wide-ranging results in the structure of toes and fingers in various species.