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Studies towards Use of Di-tert-butyl-dicarbonate Both as a Protecting and Activating Group in the Synthesis of Dipeptides
Published: 01 November 2005 by MDPI in The 9th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis
Abstract: Amide formation from amino acids was achieved in an easy and convenient one-pot procedure in chloroform or tetrahydrofuran as solvent using di-tert-butyl dicarbonate both as a protecting and an activating agent in the absence of a catalyst or coupling reagent. A number of dipeptide has been thus synthesized in good yields. The structures of the dipeptides were confirmed by IR, NMR and mass spectral data.
Keywords: Di-tert-butyl-dicarbonate, activation of carboxylic group, amino protecting-group, amide formationDi-tert-butyl-dicarbonate; activation of carboxylic group; amino protecting-group; amide formation