Studies towards Use of Di-tert-butyl-dicarbonate Both as a Protecting and Activating Group in the Synthesis of Dipeptides

S. Laulloo; A. Khodaboccus; U. Hemraz; S. Sunnassee

doi:10.3390/ecsoc-9-01489

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Enantiopure Tetrahydrofuranols by Radical Cyclization Reactions. A Simple Entry into Isodideossinucleosides

Studies towards Use of Di-tert-butyl-dicarbonate Both as a Protecting and Activating Group in the Synthesis of Dipeptides

S. Jhaumeer Laulloo

^{*

1},

A. Khodaboccus

²,

U. Hemraz

¹,

S. Sunnassee

¹ Department of Chemistry, University of Mauritius, Réduit, Mauritius
² Boehringer Ingelheim Pharmaceuticals, Ste 205 Virginia Biotech Research Park, Richmond, VA 23219, USA

Published: 01 November 2005 by MDPI in The 9th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-9-01489

Abstract: Amide formation from amino acids was achieved in an easy and convenient one-pot procedure in chloroform or tetrahydrofuran as solvent using di-tert-butyl dicarbonate both as a protecting and an activating agent in the absence of a catalyst or coupling reagent. A number of dipeptide has been thus synthesized in good yields. The structures of the dipeptides were confirmed by IR, NMR and mass spectral data.

Keywords: Di-tert-butyl-dicarbonate, activation of carboxylic group, amino protecting-group, amide formationDi-tert-butyl-dicarbonate; activation of carboxylic group; amino protecting-group; amide formation

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S. Laulloo

A. Khodaboccus

U. Hemraz

S. Sunnassee