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Access to a Key Intermediate for the Synthesis of 1-thia-analogue of Quercetin
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1  Université des Sciences et Technologies de Lille, Organic and Macromolecular Chemistry Laboratory, COM UMR 8009, Proteomics, Post-translational Modifications and Glycobiology, IFR 118, Institut Michel Eugène Chevreul (IMMCL), FR 2638, 59655 Villeneuve d’A

Abstract: We described here the access to 2-mercapto-4,6-dimethoxy-benzoic acid a key intermediate in the synthesis of the thia-analogue of quercetin. Two syntheses were attempted. The first one using a previously described strategy afforded only very modest yields of the requested compound. The second one which is original is based on the transposition by thermolysis of the appropriately functionalized phenol O-thiocarbamate precursor into the corresponding thiophenol S-thiocarbamate gave fair results which are currently under optimisation.