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Substituted 3-aminopyrazine-2,5-dicarbonitriles as New Antiinfectives
Published: 01 November 2005 by MDPI in The 9th International Electronic Conference on Synthetic Organic Chemistry session Bioorganic Chemistry and Natural Products
Abstract: A series of new pyrazinamide analogues have been prepared. Report that 5-chloropyrazinamide  has different mode of action than pyrazinamide itself  promises good chance to reach new structure with high antimycobacterial activity and new action mechanism that is realy needed because of resisance increase  to drugs in current use. Dericatives of pyrazine-2,5-dicarbonitrile promise good starting point to further studies (best activity reached yet is 3-(3-chlorophenylamino)pyrazine-2,5-dicarbonitrile, with MIC = 8µmol.l-1 against classical TBC strains and with lower activity against atypical strains. Compared to pyrazinamide with MIC = 4µmol.l-1 against classical strains and no activity against atypical ones).
Keywords: pyrazinamide; tuberculosis; antimycobacterial; antifungal