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Host-Guest Chemistry of Tolbutamide
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1  Departamento de Química Orgánica y Bio-Orgánica, Universidad Nacional de Educación a Distancia (UNED), Facultad de Ciencias, Senda del Rey 9, E-28040 Madrid, Spain

Abstract: The molecular recognition features of tolbutamide with four synthetic hosts have been studied by means of NMR titrations, NOESY experiment and Monte Carlo (MC) conformational search. The interaction strength and the most probable structure reveal new insights on the recognition phenomena of this urea derivative in comparison with close related compounds.