An efficient one-pot green synthesis of 2-alkylidene/arylidene derivatives was reported from active methylene compounds and 4-chlorobenzaldehyde in the presence of 10 mol% of boric acid in ethanol under conventional conditions. All derivatives are obtained in good to excellent yield. The structures of synthesized compounds were confirmed from their FTIR, 1H-NMR, and Mass Spectroscopy. The importance of these compounds is predicted from their SAR study.
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Unleashing the Catalytic Power of Boric Acid: Accelerating the Knoevenagel Condensation between Aldehydes and Active Methylene Compounds
Published: 26 October 2023 by MDPI in 4th International Electronic Conference on Applied Sciences session Nanosciences, Chemistry and Materials Science
Keywords: Green synthesis, boric acid, malononitrile, SAR study, Knoevenagel condensation.