Unleashing the Catalytic Power of Boric Acid: Accelerating the Knoevenagel Condensation between Aldehydes and Active Methylene Compounds

¹ Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Jharkhand, India
² Department of Chemistry, Government College of Arts and Science, Aurangabad, MS (India) - 431004G
³ Department of Chemistry, Government of Maharashtra, Government College of Arts and Science, Aurangabad (M.S.), India 431001

Academic Editor: Manoj Gupta

Published: 26 October 2023 by MDPI in The 4th International Electronic Conference on Applied Sciences session Nanosciences, Chemistry and Materials Science

https://doi.org/10.3390/ASEC2023-15366

Abstract:

An efficient one-pot green synthesis of 2-alkylidene/arylidene derivatives was reported from active methylene compounds and 4-chlorobenzaldehyde in the presence of 10 mol% of boric acid in ethanol under conventional conditions. All derivatives are obtained in good to excellent yield. The structures of synthesized compounds were confirmed from their FTIR, ¹H-NMR, and Mass Spectroscopy. The importance of these compounds is predicted from their SAR study.

Keywords: Green synthesis, boric acid, malononitrile, SAR study, Knoevenagel condensation.

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