Metal-organic frameworks (MOFs) are a class of material made up of metal ions or clusters and organic linkers. Cyclodextrin-based MOFs (CD-MOFs) are gaining popularity among MOFs due to their unique features, such as high porosity, permanent porosity, and biocompatibility. This paper focuses on recent advances in the synthesis of CD-MOFs and their water stability. We highlight the difficulties involved with CD-MOF synthesis and the strategies that have been explored to increase their water stability. Finally, we discuss the current research gaps and the future outlook of CD-MOF research.