We present a smart optoelectronic system for fluid sensing by measuring the laser beam displacement induced by the difference in refractive index between liquids. In the experimental configuration, the radiation provided by a red laser diode impinges obliquely the flat surface of a plastic cuvette containing the fluid under test. After being reflected by a mirror glued onto the back side of the cuvette, thus after crossing the channel of the cuvette twice, the radiation exits the cuvette in different positions when fluids with different refractive index fill its channel, according to Snell law, and it finally reaches the active surface of a position sensitive detector (PSD). We retrieved the position of the output light beam onto the PSD as p_PSD = L/2 × (V₁ – V₂)/(V₁ + V₂), where L is the length of the active surface, V₁ and V₂ are the voltage output signals, proportional to the photocurrents I₁ and I₂ generated at the extremities of the sensitive area. The output signals provided by the PSD are visualized in real-time and acquired with an oscilloscope. Data are elaborated in MATLAB environment. We exploited the sensing platform to distinguish fluids for artificial parenteral nutrition on the basis of their refractive indices, that are determined by knowing the different concentrations of solutes such as glucose, amino acids and electrolytes. We developed a model based on ray optics in MATLAB environment: experimental results were found in good agreement with the simulations provided by the model. We successfully demonstrated the detection of artificial parenteral nutrition fluid with high sensitivity by exploiting a totally remote, non-invasive approach with the use of just a few low-cost optical elements and a biocompatible standard cuvette.