The purpose of the present investigation was to formulate a mouth-dispersing film of clopidogrel hydrogen sulphatedosage form for a rapid onset of action, which is very easy for administration, without the issue of swallowing and using water. The mouth dissolving film of Clopidogrel hydrogen sulphate was prepared by Solvent Casting Method and its’ in-vitro characterisation was evaluated. Its tensile strength is 3.68 N/ Cm². The drug content ranges from95.20 to97.5 %. The drug release rate of the optimized formula A4 is 99.58 % in 5 minutes, and it was concluded according to this result, that the film prepared by HPMC E5 polymer is forming superior filmthat offers rapid drug release.