The urban regeneration is not only an opportunity for the city to adapt according to criteria of resilience to climate change; it is also a significant opportunity to build a city based on an approach to health that places the human person at the centre of the whole system. According to World Health Organization criteria, health means not only the absence of disease but the broader well-being understood as a complex of socio-economic, biological and environmental relationships. We want to present some results of applying this human-centred approach where the shape, texture and materials of the urban fabric are essential to building the boundary conditions for developing a healthy-city. In particular, the analysis will focus on the weaker segments of the population. Not only the protection of the vulnerable is being analysed, but also the inclusion processes that urban regeneration can trigger when they become an integral part of the planning.