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Development of Multi-Gram Scale Microwave Assisted Organic Synthesis (MAOS): Suzuki Coupling towards 2,4-Dimethyl-8-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-5,8-dihydro-6H-pyrido[2,3-d]pyrimidin-7-one (Tasosartan)
1 , * 1 , 2 , 2
1  Institute of Applied Synthetic Chemistry, Vienna University of Technology, Getreidemarkt 9, 1060 Vienna, Austria
2  Institute of Chemistry, Karl Franzens Universität Graz, Heinrichstrasse 28, 8010 Graz, Austria

Abstract: The improved synthesis of 2,4-dimethyl-8-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-5,8-dihydro-6H-pyrido[2,3-d] pyrimidin-7-one (tasosartan-1, click for 3D-structure) on multigramscale is described. The synthesis was developed in context of the DrugMatrix-genomics project.
Keywords: angiotensine II antagonist; Suzuki-coupling; microwave