In this research endeavor, we introduce a novel and innovative approach that incorporates anaerobic acetogenic pretreatment in conjunction with aerobic polishing to address the issue of textile processing wastewater. This approach deviates from the commonly employed traditional extended aeration methods within the industry by setting itself apart through its notably heightened energy efficiency. Our study thoroughly investigated the efficacy of deploying a fusion of anaerobic acetogenic pretreatment and aerobic polishing within the realm of textile processing wastewater treatment, placing a specific emphasis on its potential for large-scale implementation to repurpose the treated effluent in wet processing applications. This comprehensive research was conducted in a two-phase process, commencing with bench-scale experimentation and subsequently scaling up for practical industrial application. The experimental procedure entailed the utilization of wastewater sourced from the equalization basin of a textile wastewater treatment facility. The experimental reactors were meticulously operated on a laboratory scale, with stringent control over specific conditions. The acetogenic reactor operated continuously in a washout mode, experiencing daily episodes of sudden aeration, while the aerobic reactor maintained continuous aeration. Significantly, the anaerobic acetogenic pretreatment process exhibited remarkable efficacy in the removal of color, whereas the aerobic process excelled in the reduction of the majority of COD. By amalgamating these anaerobic acetogenic pretreatment and aerobic processes, substantial reductions in COD, BOD, color, and TDS were achieved, with reductions of up to 95%, 94%, 96%, and 87%, respectively. The treated wastewater found efficient repurposing within the denim and knit manufacturing facility, predominantly serving wet processing needs. The implementation of the anaerobic acetogenic pretreatment method not only fosters a more environmentally conscious approach to wastewater treatment but also assures a diminished carbon footprint. This aligns perfectly with the overarching objective of efficient wastewater treatment and the promotion of sustainable development, rooted in the fundamental principles of a circular economy.