Antibiotic resistance has posed a major public health challenge because of antibiotics misuse, overdose, under dose, ignorance on antibiotics usage and substandard production from the producers, thus the need for an alternative antibiotic agent production. Here, a commonly used antibiotic plant, Chrysophyllum albidum leaf was used to produce silver nanoparticle (AgNPs) and characterized using XRD, FTIR, DSC, DLS and SEM. The characterization data showed the production of a 6 weeks stable AgNPs, with high antioxidant properties and amylase, glucosidase and cholinesterases inhibition properties. Similarly, the product exhibited stable antibiotics properties on Escherichia coli, Klebsiella pneumoniae and Staphylococcus aureus after 6 weeks of storage at 4°C.