Additive manufacturing allows the creation of geometries otherwise impossible to achieve through traditional technologies in mechanical components. These geometries can be obtained using algorithms to optimize the mass distribution. Topology Optimization algorithms are one of the tools most applied in design for additive manufacturing and lightweight engineering. These optimization techniques require Finite Element Method tools to evaluate and compare the mechanical behavior of different geometrical solutions. The optimization results are closely related to boundary conditions, objectives, and constraints. Therefore, one of the issues is the necessity to evaluate different parameter settings to improve the result in terms of lightweight, strength, and easy printability. This article shows a working method to use topological optimization for lightening a connecting rod. The resultant model is optimized considering Additive Manufacturing.