Bacterial citrus canker disease (BCCD), caused by Xanthomonas citri subsp. citri (Xcc) is considered one of the most damaging factors to the citrus industry worldwide. Recently, based on the host range and pathogen interactions, five different pathovars of the BCCD have been extensively investigated, in which pathotype A (the Asiatic form of X. citri subsp. citri) being the most devastative and widespread among almost all citrus varieties and their relative. The disease causative agent (Xcc) induces varying symptoms depending on the citrus species, plant part, age, geographical area, and climate conditions. The symptoms ranging from small and raised yellowish to necrotic lesions containing corky tissues surrounded by watery and clear yellow rings on leaves, stems, and fruits. In a high level of BCCD, severe symptoms may occur such as die-back, defoliation, severe fruit dropping, and blemished, which remarkably reduce fruit production and quality. Based on all published articles about BCCD in Sudan from the first detection in 2013 to date, the current study aimed to highlight the starting point of BCCD in a specific region in eastern Sudan, the path of spread to cover almost all citrus-producing areas in Sudan, Symptomatology, Xcc identity, ecology, and assessing the efficacy of various chemical compounds and plant extracts against Xcc through both in vivo and in vitro examinations to establish an effective strategy to manage this disease