The Synthesis and Pharmacological Evaluation of 2,3 "seco" Fentanyl

Ivan Micovic; M. Ivanovic; Vesna Kiricojevic; Sonja Vuckovic; Ljiljana Dosen-Micovic

doi:10.3390/ecsoc-2-01699

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Design and Synthesis of a Photoaffinity Label for the Enzyme Tocopherol Cyclase

The Synthesis and Pharmacological Evaluation of 2,3 "seco" Fentanyl

Ivan V. Micovic

^{*

1},

M. D. Ivanovic

^{*

2},

Vesna D. Kiricojevic

^{*

2},

Sonja Vuckovic

^{*

3},

Ljiljana Dosen-Micovic

^{*

1}

¹ Department of Chemistry, University of Belgrade, Studentski trg 16. P.O Box 550, Yu-550 11001, Belgrade, FR Yugoslavia
² Institute for Chemistry, Technology and Metalurgy, Center for Chemistry, Studentski trg 16, 11001, Belgrade, FR Yugoslavia
³ Department of Pharmacology, Toxicology and Clinical Pharmacology, Medical Faculty, P.O. Box 662

Published: 01 November 1998 by MDPI in The 2nd International Electronic Conference on Synthetic Organic Chemistry session Medicinal and Bioorganic Application of Organic Synthesis

https://doi.org/10.3390/ecsoc-2-01699

Abstract: A structurally novel, 2,3 seco analogue of fentanyl has been synthesized by a short and efficient procedure. Central-analgesic activity was found to be ca. 30 times lower than fentanyl but still several times higher than morphine.

Keywords: Fentanyl, open-chained analogues, central analgesics

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Ivan Micovic

M. Ivanovic

Vesna Kiricojevic

Sonja Vuckovic

Ljiljana Dosen-Micovic