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The Synthesis and Pharmacological Evaluation of 2,3 "seco" Fentanyl
Published: 01 November 1998 by MDPI in The 2nd International Electronic Conference on Synthetic Organic Chemistry session Medicinal and Bioorganic Application of Organic Synthesis
Abstract: A structurally novel, 2,3 seco analogue of fentanyl has been synthesized by a short and efficient procedure. Central-analgesic activity was found to be ca. 30 times lower than fentanyl but still several times higher than morphine.
Keywords: Fentanyl, open-chained analogues, central analgesics