The Synthesis and Pharmacological Evaluation of 2,3 "seco" Fentanyl

¹ Department of Chemistry, University of Belgrade, Studentski trg 16. P.O Box 550, Yu-550 11001, Belgrade, FR Yugoslavia
² Institute for Chemistry, Technology and Metalurgy, Center for Chemistry, Studentski trg 16, 11001, Belgrade, FR Yugoslavia
³ Department of Pharmacology, Toxicology and Clinical Pharmacology, Medical Faculty, P.O. Box 662

Published: 01 November 1998 by MDPI in The 2nd International Electronic Conference on Synthetic Organic Chemistry session Medicinal and Bioorganic Application of Organic Synthesis

https://doi.org/10.3390/ecsoc-2-01699

Abstract: A structurally novel, 2,3 seco analogue of fentanyl has been synthesized by a short and efficient procedure. Central-analgesic activity was found to be ca. 30 times lower than fentanyl but still several times higher than morphine.

Keywords: Fentanyl, open-chained analogues, central analgesics

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Ljiljana Dosen-Micovic