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The T1 Linker: Multidirectional Cleavage for Solid Phase Organic Synthesis.
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1  RWTH Aachen, Institut für Organische Chemie, Professor-Pirlet-Str. 1, D-52074 Aachen, Germany

Abstract: The T1 linker for the attachment of arenes has been described. Various transformations yielded modified arenes. The cleavage from the resin has been conducted to give hydrocarbons ("Traceless linker"), heterocycles (Richter reaction), arylated, alkenylated and alkylated arenes (Heck cleavage protocol), haloarenes, phenols, biaryls and azo compounds. This method is applicable to parallel synthesis and automation.
Keywords: n/a