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Synthesis of Heterocycles Using Tandem Cyclization Processes.
1  Department of Chemistry, Emory University, Atlanta, GA 30322 USA

Abstract: Various applications of the cycloaddition/N-acyliminium ion tandem cyclization cascade are outlined in this electronic symposium on synthetic organic chemistry. The key step in the process involves the generation of a reactive N-acyliminium ion by fragmentation of an amino substituted [4+2]-cycloadduct. The successful synthesis of a number of alkaloids by this sequence of reactions reveals the usefulness and importance of this unique domino cascade.
Keywords: n/a