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Synthesis of Heterocycles Using Tandem Cyclization Processes.
Published: 01 November 1999 by MDPI in The 3rd International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis
Abstract: Various applications of the cycloaddition/N-acyliminium ion tandem cyclization cascade are outlined in this electronic symposium on synthetic organic chemistry. The key step in the process involves the generation of a reactive N-acyliminium ion by fragmentation of an amino substituted [4+2]-cycloadduct. The successful synthesis of a number of alkaloids by this sequence of reactions reveals the usefulness and importance of this unique domino cascade.