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Coupling of Phenols to 2-Chlorotrityl Resins under Non-basic Conditions
* 1 , 2
1  Argonaut Technologies AG, P.O. Box 43, CH-4132 Muttenz 2, Switzerland
2  Combinatorial Chemistry Unit, Core Technology Area, Novartis Pharma Inc., CH-4002 Basel, Switzerland

Abstract: A new procedure for the coupling of phenols to 2-chlorotrityl resins has been developed using polymer bound 2-pyridyl ether derivative 1 as tritylation agent. The method allows the immobilisation of phenols under non-basic conditions and is particularly suited for base sensitive phenolic compounds. Scope and limitation of this new coupling method have been investigated.
Keywords: n/a