Substrate Transport Limitation as tool to enhance enantioselectivity in the enzyme synthesis of chiral cyanohydrins

Pieter Gerrits; Johannes Brussee; Arne van der Gen

doi:10.3390/ecsoc-3-01763

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Substrate Transport Limitation as tool to enhance enantioselectivity in the enzyme synthesis of chiral cyanohydrins

Pieter Jan Gerrits

^*,

Johannes Brussee

Arne van der Gen

¹ Leiden Institute of Chemistry, Gorlaeus Laboratories, Leiden University, P.O. Box 9502, NL-2300 RA Leiden, The Netherlands

Published: 01 November 1999 by MDPI in The 3rd International Electronic Conference on Synthetic Organic Chemistry session Medicinal and Bioorganic Application of Organic Synthesis

https://doi.org/10.3390/ecsoc-3-01763

Abstract: Objective: Rational design of process characterized by: two-phase (fed) batch system, the use of purified oxynitrilase, enantiomerically pure products (ee > 98%), high yield and through-put (mol.l-1.h-1), down stream processing with respect to recycling of enzyme and solvents

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Pieter Gerrits

Johannes Brussee

Arne van der Gen