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Substrate Transport Limitation as tool to enhance enantioselectivity in the enzyme synthesis of chiral cyanohydrins
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1  Leiden Institute of Chemistry, Gorlaeus Laboratories, Leiden University, P.O. Box 9502, NL-2300 RA Leiden, The Netherlands

Abstract: Objective: Rational design of process characterized by: two-phase (fed) batch system, the use of purified oxynitrilase, enantiomerically pure products (ee > 98%), high yield and through-put (mol.l-1.h-1), down stream processing with respect to recycling of enzyme and solvents
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