Arene-Catalysed Reductive Cleavage of the Benzylic Carbon-Sulfur Bond: Generation of Benzylic Lithium Reagents.

E. Alonso; J. Ferrandez; F. Foubelo; I. Gomez; D. Guijarro; A. Gutierrez; P Martinez; O. Prieto; D. Ramon; T. Soler; M. Yus

doi:10.3390/ecsoc-4-01801

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Asymmetric Synthesis of Functionalized Prolines by Diastereoselective 1,3-Dipolar Cycloaddition Using Chiral Oxazinone Derivatives

Arene-Catalysed Reductive Cleavage of the Benzylic Carbon-Sulfur Bond: Generation of Benzylic Lithium Reagents.

E. Alonso

J. V. Ferrandez

F. Foubelo

I. Gomez

D. Guijarro

A. Gutierrez

P J. Martinez

O. Prieto

D. J. Ramon

T. Soler

M. Yus

¹ Departamento de Quimica Organica, Universidad de Alicante, E-03080 Alicante, Spain

Published: 11 September 2000 by MDPI in The 4th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-4-01801

Abstract: The reductive cleavage of benzylic carbon-sulfur bonds via an arene-catalysed lithiation process is described. The benzyllithium reagents generated were reacted with several electrophiles, mainly carbonyl compounds, affording the expected products in moderate to good yields.

Keywords: arene-catalysed lithiation, benzyllithium, carbon-sulfur bond cleavage

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