Three-dimensional (3D) printing technology has revolutionized the field of tissue engineering, particularly in the development of scaffolds for craniomaxillofacial (CMF) bone regeneration. Till today, a question remains regarding the use of 3D-printed nanocomposite scaffolds incorporating metallic or gold nanoparticles for craniomaxillofacial bone regeneration. In this research study, we aim to develop 3D-printed nanocomposite scaffolds tailored with various bioactive materials and nanotechnologies, offering a significant advancement in the field of CMF bone regeneration. Gelatin methacryloyl (GelMA) was selected as a bioink candidate for its biocompatibility and tunable mechanical properties. Surface-engineered gold nanoparticles (AuNPs) were incorporated to enhance the rheological properties, conductivity, and printability of the bioink. The integration of bioactive molecules, such as small-chain amino acids conjugated to gold nanoparticles (AuNPs), had the potential to contribute to bone healing and regeneration. The improvements in biological, electrical, and rheological characteristics facilitated enhanced differentiation of encapsulated stem cells and enabled the fabrication of highly viable and stable constructs. These findings hold significant potential to advance 3D bioprinting capabilities, offering a promising avenue for the fabrication of precise and biologically relevant tissue constructs for applications in regenerative medicine and personalized therapeutic interventions. These scaffolds can be customized to the specific needs of the defect site, thereby improving the outcomes of bone regeneration therapies.
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3D-Printed Nanocomposite Scaffolds for Bone Tissue Regeneration
Published:
08 July 2024
by MDPI
in The 1st International Online Conference on Functional Biomaterials
session Biomaterials for Tissue Engineering
Abstract:
Keywords: 3D Bioprinting, Gold nanoparticles, Bone regeneration, Tissue engineering, Periodontal ligament stem cells
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