In the realm of combating antimicrobial resistance (AMR) and tackling infections triggered by priority pathogens outlined in the ESKAPE acronym by WHO, the development of innovative antibacterial biomaterials through novel multifunctional rhenium and iridium flavonoid complexes holds significant promise. In the MET-EFFECT project (funded MSCA-SE, Horizon Europe, https://met-effect.com) groundbreaking concept of using novel multifunctional rhenium and iridium flavonoid complexes as both metallodrugs and homogeneous catalysts is proposed. By leveraging the synergistic potential of these complexes, which act both as metallodrugs and homogeneous catalysts, advanced solutions for countering ESKAPE pathogen infections can be crafted. These biomaterials represent a beacon of hope in addressing the pressing challenges posed by antimicrobial resistance, thus bolstering patient outcomes within healthcare environments. Integration of rhenium and iridium flavonoid complexes into composite biomaterials, such as hydrogels, films, or coatings, stands as a pivotal strategy for antimicrobial applications. Within these biomaterial matrices, these complexes serve dual roles as both antimicrobial agents and catalysts, effectively combating infections brought about by ESKAPE pathogens. By incorporating flavonoid ligands renowned for their antimicrobial properties, such complexes disrupt bacterial cell membranes or impede crucial metabolic pathways, ultimately leading to bacterial demise. Furthermore, these multifunctional complexes can be tailored to selectively target specific bacterial species within the ESKAPE group, such as Staphylococcus aureus or Klebsiella pneumoniae, while mitigating adverse effects on commensal bacteria or host cells. This targeted approach significantly enhances the efficacy and safety profile of the metallodrugs. Emphasis on the design of antibacterial biomaterials incorporating rhenium and iridium complexes prioritizes biocompatibility and safety. Formulations are meticulously optimized to minimize cytotoxicity and immunogenicity, thereby ensuring seamless compatibility with host tissues and cells.