Background: In the disciplines of orthopedics and dentistry, acrylic bone cement is frequently utilized for treating bone defects, securing prosthetic implants, remodeling osteoporotic deformities, and repairing fractures. Traditional acrylic bone cement has been found to have several disadvantages, such as prosthesis loosening, heat generation, inferior mechanical characteristics, and weak interface integrity. There was a strong need to improve its qualities; as such, recent research has shown that adding halloysite clay nanotubes (HNTs) to materials based on polymers can enhance their mechanical and thermal qualities. Objectives: We sought to assess the impact of adding 10 weight percent of HNT fillers to traditional acrylic bone cements in order to modify their compressive strength, flexural strength, and exothermic heat generation. Methods: The monomer liquid was combined with acrylic powder to create the control group. The creatively reinforced group was made by combining the acrylic powder with liquid before adding 10 weight percent of HNT fillers. XRF was used to carry out the chemical characterization of the fillers that were used. Measurements were made of the setting temperature, compressive strength, and flexural strength. Independent sample t-tests were used to statistically analyze the data and compare the mean values (p < 0.05). Results: The results showed that when compared to the traditional acrylic bone cement control group, the novel modified acrylic bone cement with 10 weight % HNT fillers had greater mean compressive strength, greater flexural strength, and lower setting temperatures (P≤0.05). Conclusion: It was possible to employ the modified reinforced acrylic bone cement with 10% HNT fillers as an alternative to acrylic bone cement.