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4,5-Disubstituted Pyrrolidin-2-ones starting from D-Xylose
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1  Dipartimento di Scienze dei Materiali e della Terra - Universita di Ancona Via Brecce Bianche I-60131 - Ancona, Italy

Abstract: Several non-proteinogenic amino acids containing the pyrrolidine ring show high affinity towards NMDA (N-methyl-D-aspartic acid) and glutamate receptors. Thus, they can be employed in order to establish the mechanisms involved in transmission of nerve impulse. Moreover, they can be used for treatmentment of CNS diseases. Among them, 2- carboxy-3-pyrrolidinacetic acid (CPAA), 1, and the diastereomeric 2-carboxy-4-(2-methoxyphenyl)-3- pyrrolidineacetic acids 2 and 3 are significant examples
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