4,5-Disubstituted Pyrrolidin-2-ones starting from D-Xylose

Christiana Fava; Roberta Galeazzi; Giovanna Mobbili; Mario Orena

doi:10.3390/ecsoc-4-01818

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A Comparison of Two Effective Chiral Auxiliaries - (2R)-bornane-10,2-sultam and (2R)-bornane-10,2-cyclohydrazide - using the [4+2] Cycloaddition of Cyclopentadiene to their N,N'-fumaroyl derivatives

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New Fluorous Chiral Phosphorous Ligands Based on the Binaphthyl Skeleton

4,5-Disubstituted Pyrrolidin-2-ones starting from D-Xylose

Christiana Fava

Roberta Galeazzi

Giovanna Mobbili

Mario Orena

¹ Dipartimento di Scienze dei Materiali e della Terra - Universita di Ancona Via Brecce Bianche I-60131 - Ancona, Italy

Published: 11 September 2000 by MDPI in The 4th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-4-01818

Abstract: Several non-proteinogenic amino acids containing the pyrrolidine ring show high affinity towards NMDA (N-methyl-D-aspartic acid) and glutamate receptors. Thus, they can be employed in order to establish the mechanisms involved in transmission of nerve impulse. Moreover, they can be used for treatmentment of CNS diseases. Among them, 2- carboxy-3-pyrrolidinacetic acid (CPAA), 1, and the diastereomeric 2-carboxy-4-(2-methoxyphenyl)-3- pyrrolidineacetic acids 2 and 3 are significant examples

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Christiana Fava

Roberta Galeazzi

Giovanna Mobbili

Mario Orena