The expansion of rubber plantations in tropical regions presents a significant challenge and opportunity for balancing economic development with ecological integrity. This study explores the complex interplay between the rubber industry and the conservation of ecosystem services, conceptualizing eco-economic frontiers as zones where economic and ecological interests converge. By combining economic analysis, ecological assessment, and social considerations, we evaluate the sustainability of rubber plantations across various landscapes. Our framework incorporates case studies from Southeast Asia, Africa, and Latin America, with a detailed analysis of 10 specific case studies, highlighting global implications and regional variations in rubber cultivation. The findings reveal that while rubber plantations can significantly contribute to rural development and global markets—covering over 14 million hectares and supporting approximately 10 million livelihoods—they often lead to biodiversity losses, altered hydrological cycles, and decreased ecosystem service quality. For example, in Southeast Asia, rubber plantations have been linked to a 60% reduction in local biodiversity, while in Africa, land-use changes have caused up to a 20% decrease in annual water flow. To address these challenges, we propose best management practices and policy recommendations aimed at optimizing production efficiency while minimizing ecological footprints. These include adopting agroforestry systems, improved land-use planning, and integrating ecosystem service valuation in decision-making. Specifically, agroforestry systems can enhance biodiversity by up to 40% and improve soil quality and water retention, supporting both productivity and ecosystem health. Through our innovative contributions, we provide a comprehensive understanding of the trade-offs and synergies between rubber plantation profitability and ecosystem service conservation. This study contributes to the sustainable land use debate and offers a blueprint for reconciling economic and environmental objectives in the context of global change. By fostering a better understanding of these dynamics, we aim to inform policy and practice, guiding future efforts towards sustainable rubber plantation management.