Rice Bran Oil May Improve Glycemic Control, Alleviate Lipid Peroxidation and Improve Antioxidant Defense in Overweight/Obese Adults with Metabolic Syndrome

Zeinab Ghorbani; Marjan Mahdavi-Roshan; Nargeskhatoon Shoaibinobarian; Mehdi Evazalipour; Arsalan Salari; amir savarrakhsh; zahra Ahmadnia

Previous Article in event

Brown rice bran powder, when added to the standard diet, could alleviate cardiometabolic risk factors and antioxidant status in patients with metabolic syndrome

Next Article in event

Development of Herbal Tea Formulations from Citrus microcarpa (Calamansi), Mangifera indica (Mango), and Zingiber officinale (Ginger) Peels and the Evaluation of the Antioxidant and Sensory Profiles of their Infusions

Rice Bran Oil May Improve Glycemic Control, Alleviate Lipid Peroxidation and Improve Antioxidant Defense in Overweight/Obese Adults with Metabolic Syndrome

Zeinab Ghorbani

^{*

1},

Marjan Mahdavi-Roshan

^{*

2, 3},

Nargeskhatoon Shoaibinobarian

⁴,

Mehdi Evazalipour

²,

Arsalan Salari

²,

amir savarrakhsh

²,

zahra Ahmadnia

¹ Cardiovascular Diseases Research Center, Department of Cardiology, Heshmat Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
² Guilan University of Medical Sciences
³ Department of Clinical Nutrition, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
⁴ Islamic Azad University

Academic Editor: Elad Tako

Published: 11 October 2024 by MDPI in The 4th International Electronic Conference on Nutrients session Innovation in Dietary Choices

Abstract:

Introduction: We previously documented the beneficial effects of rice bran oil (RBO) on cardiac function, and on atherogenic cardiometabolic factors of men with coronary artery disease. Hence, in the current trial, we aimed at extending these findings by exploring the effects of this healthy oil on the metabolic profile, novel insulin resistance surrogate markers, lipid peroxidation, and antioxidant status of overweight/obese men and women with metabolic syndrome (MetSyn).

Methods: A total of 50 overweight/obese adults (mean body mass index (BMI) = 31.08 kg/m2) with at least 3 MetSyn components were randomly allocated to either a control group, who received standard diet plan, or intervention, who were additionally supplemented with 30g/d of RBO for 8 weeks. BMI, MetSyn components, metabolic score for insulin resistance (METS-IR), triglyceride-glucose–BMI index (TyG-BMI), malondialdehyde (MDA), total antioxidant capacity (TAC), and plasma polyphenols levels were measured before and after this open-label trial.

Results: Analysis of covariance (ANCOVA) adjusted for baseline values revealed that compared to the patients who only received the standard diet plan, those who were additionally supplemented with 30g/d RBO demonstrated significantly reduced total cholesterol (P-value =0.005; effect size(ES):-0.92), LDL-cholesterol (P-value=0.048; ES:-0.62), fasting blood sugar (P-value =0.014; ES:-0.77), MDA (P-value =0.002; ES: -1.01), METS-IR (P-value<0.001; ES: -1.24); and TyG-BMI (P-value=0.007; ES:-0.85) after 8 weeks. Additionally, RBO consumption resulted in significantly higher levels of HDL-cholesterol (P-value=0.004; ES:0.94) and TAC (P-value<0.0001; ES:2.05). However, no significant changes were noted regarding BMI, waist circumference, serum triglyceride, plasma polyphenols, and blood pressure.

Conclusion: Dietary supplementation with RBO in addition to standard diet could be an effective complementary option for MetSyn, considering its hypocholesterolemic, antihyperglycemic, and antioxidative effects, and alleviating lipid peroxidation in these with patients.

Keywords: antioxidant, glycemia, lipid profile, metabolic factors, oxidative stress, RBO.

0 Reads
0 Recommendations

Comments on this paper

Currently there are no comments available.