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A Chiral Silyl Ether as Auxiliary for the Asymmetric Nucleophilic Addition to a- and b-Silyloxy Carbonyl Compounds
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1  Org.-chem. Institut, Universität Zürich, Winterthurerstrasse 190, 8057 Zürich

Abstract: Silyl ethers are well established protective groups in organic synthesis [1]. They are easily prepared and cleaved, and their reactivity can readily be controlled by the appropriate choice of the groups attached to silicon. In the course of our ongoing investigation of the chiral (tert-butyl)(methyl)(benzyloxymethyl)silyl group (I) as an auxiliary to control stereoselective processes [2] we got interested in the combined use of I as a protective and stereochemically directing group.
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