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Enantioselective hydride abstraction in organic substrates: future applications for chiral carbenium ions
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1  Department of Chemistry, University of California at Santa Barbara, Santa Barbara, CA 93106 USA

Abstract: Oxidation reactions are at the core of asymmetric chemistry. It is therefore surprising, in view of the potential applications, not to find any instances of the notion of using a "chiral cation" to distinguish between a pair of prochiral hydrides during hydride transfer [H-T]. To the best of our knowledge, there are none. Yet, the converse concept of using a "chiral anion" to distinguish between a pair of prochiral protons during a deprotonation has led to significant advancements in the field of asymmetric synthesis.[1] This letter describes the first example of an enantioselective [HT]
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