Sindh Province has experienced significant alterations in temperature and precipitation, resulting in heightened occurrences of extreme weather like heatwaves, droughts, and floods, exacerbating environmental challenges in frequency and intensity. This study utilized the multi-model ensemble of the climate models from the Coupled Model Intercomparison Project Phase 6 (CMIP6) to analyze historical and future climatic projections in Sindh Province, Pakistan. This study aim to develop high-resolution, region-specific estimates that capture the subtle implications of various climatic scenarios and Shared Socioeconomic Pathways (SSPs) using modern climate models and downscaling approaches. These changes in climate have amplified the occurrence and intensity of various environmental challenges. The findings are categorized into two time periods: the near future (2030-2060) and the far future (2060-2100) under the Shared Socioeconomic Pathways (SSPs). This study aims to increase scientific knowledge of how Sindh Province is being affected and will be affected by climate change. The results show that the temperature will continue to increase in the future in Sindh. However, models project uncertain precipitation patterns, including an increased frequency of extreme events (floods, heatwaves, and droughts) in this region. The insights will help policymakers and water managers in preparing sustainable and climate-resilient water management strategies in this region.