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A New Binding Motif for Amidinium Cations � Strong Binding of Amidinium Salts with m-Xylylene Bisphosphonate Moieties
Published: 11 September 2000 by MDPI in The 4th International Electronic Conference on Synthetic Organic Chemistry session Bioorganic Chemistry and Natural Products
Abstract: In contrast to the multitude of different binding motifs for the molecular recognition of ammonium cations very few efficient guanidinium receptors have been reported and even less amidinium hosts . The latter is surprising in view of important role of the amidinium functionality in drugs targeting binding pockets for the arginine sidechain etc. The challenge, however, is quite clear: One has to surround the amidinium group in a halfmoon-like array with at least four hydrogen bond acceptors, which are ideally preoriented for maximum electrostatic as well as hydrogen bond interactions.