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A New Binding Motif for Amidinium Cations � Strong Binding of Amidinium Salts with m-Xylylene Bisphosphonate Moieties
1 , * 2
1  Institut für Organische Chemie und Makromolekulare Chemie, Heinrich-Heine-Universität Düsseldorf, Universitätsstr. 1, D-40225 Düsseldorf, Germany
2  Fachbereich Chemie, Philipps-Universität Marburg, Hans-Meerwein-Straße, D-35032 Marburg, Germany

Abstract: In contrast to the multitude of different binding motifs for the molecular recognition of ammonium cations very few efficient guanidinium receptors have been reported and even less amidinium hosts [1]. The latter is surprising in view of important role of the amidinium functionality in drugs targeting binding pockets for the arginine sidechain etc. The challenge, however, is quite clear: One has to surround the amidinium group in a halfmoon-like array with at least four hydrogen bond acceptors, which are ideally preoriented for maximum electrostatic as well as hydrogen bond interactions.
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