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A Model Study for a Novel Synthetic Approach to 2-Carboxyinosines
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1  Laboratory for Drug Design and Synthesis Department of Chemistry & Biochemistry University of Maryland, Baltimore County 1000 Hilltop Circle, Baltimore, Maryland 21250, USA

Abstract: A model study for a novel approach to the synthesis of 2-carboxyinosines has been described. The synthesis of 9-benzyl-2-carboxyhypoxanthine (I), a model for 2-carboxyinosine, was achieved in 4 steps starting from 1-benzyl-5-nitroimidazole-4-carboxylic acid. Also reported is the synthesis of 9-benzyl-2,2-bis(ethoxycarbonyl)hypoxanthine (II).
Keywords: hypoxanthines, 2-substitution, 2,2-disubstitution, 2-carboxyhypoxanthine, 2,2-dicarboxylic acid ester