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Alkylation of carboxylic acids in a microfluidic device: kinetics parameters determination, Hammett reaction constant measurement and optimization of preparative experiment
Published: 31 October 2009 by MDPI in The 13th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis
Abstract: A new proton sponge 1,8-bis(tetramethylguanidino)naphthalene (TMGN) was utilized for the alkylation of benzoic acid by iodomethane in a continuous flow microsystem. Using this set-up, kinetics of the reaction was determined in different mixing strategies and the Hammett reaction constant was measured. Good performance and efficiency of this procedure were confirmed through several preparative studies.