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Alkylation of carboxylic acids in a microfluidic device: kinetics parameters determination, Hammett reaction constant measurement and optimization of preparative experiment
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1  Université de Lille 1, Sciences et Technologies, UMR CNRS USTL 8009, Organic and Macromolecular Chemistry, FR CNRS USTL 2638, Eugène-Michel CHEVREUL Institute, Villeneuve d’Ascq, France

Abstract: A new proton sponge 1,8-bis(tetramethylguanidino)naphthalene (TMGN) was utilized for the alkylation of benzoic acid by iodomethane in a continuous flow microsystem. Using this set-up, kinetics of the reaction was determined in different mixing strategies and the Hammett reaction constant was measured. Good performance and efficiency of this procedure were confirmed through several preparative studies.
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Alisa Ortiz
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