Transdermal matrices modified with proteins and peptides containing adaptogens represent a promising approach in skin therapy and care. Adaptogens, known for their antioxidant properties and stress-resistance benefits, have been incorporated into transdermal matrices to support skin regeneration and protection. Modification with proteins and peptides enhances the stability and efficacy of active ingredient transport across the skin barrier, enabling gradual and controlled release. The study examined the physicochemical properties, stability of the matrices, and the effectiveness of adaptogens in reducing oxidative stress and supporting skin regeneration processes. Results indicate that these matrices could be an effective tool in treating inflammatory conditions and skin aging processes, opening new possibilities for applications in dermatological and cosmetic products. The potential of this technology could contribute to the development of innovative therapies that support skin health.

Acknowledgments: The project is financed with funds from the state budget granted by the Minister of Science within the framework of the "Student Scientific Clubs Create Innovations" (SKN/SP/601893/2024) "Application of Biohydrogels Containing Adaptogens in Innovative Chronic Wound Therapy" .The research work was carried out within the SMART-MAT Functional Materials Science Club (section Smart-Mat) at the Faculty of Materials Engineering and Physics of the Cracow University of Technology.