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(S)-6-Isopropyl-5-Phenyl-1,2,3,6-Tetrahydro-2-Pyrazinone: A New Chiral Glycine Equivalent for the Synthesis of (Z)-a,b-Didehydro-a-Amino Acid Derivatives
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1  Departamento de Quimica Organica, Universidad de Alicante. E-03080 Alicante, Spain.

Abstract: The preparation of N-Boc-protected (S)-6-isopropyl-5-phenyl-1,2,3,6-tetrahydro-2-pyrazinone from (S)-valine and glycine in seven steps and its reactivity with carbonyl compounds affording stereoselectively (Z)-didehydroamino acids derivatives is reported in this communication.
Keywords: Amino acids-didehydro, phase-transfer catalysis, carbonyl compounds, tetrahydro-2-pyrazinone.