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Synthesis of 5-BromoVerongamine, an Antibacterial Dibromotyrosine Metabolite from Pseudoceratina sponge
Davis E. Yakubu
,
Philppos Konstanidis
,
Mark Gray
,
Anthony O’Shaughnessy
,
J. Jonathan Harburn
* ,
Suresh K. Kottakota
1  Sunderland Pharmacy School, University of Sunderland, Wharncliffe Street, Sunderland, SR1 3SD, UK
Published: 01 November 2009 by MDPI in The 13th International Electronic Conference on Synthetic Organic Chemistry session Bioorganic Chemistry and Natural Products
https://doi.org/10.3390/ecsoc-13-00202
Abstract: 5-BromoVerongamine has been successfully synthesized in 2 steps in good yield from readily available starting materials. Structural elucidation has been confirmed through direct comparison with spectroscopic data of isolated natural product. 5-BromoVerongamine has been shown to have moderate bacteriacidal activity against MRSA.
Keywords: marine sponge metabolites, bromotyramine, bromotyrosine, anti-bacterials
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Natasha Quentin
27 July 2018
EDUR
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