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Synthesis of 5-BromoVerongamine, an Antibacterial Dibromotyrosine Metabolite from Pseudoceratina sponge
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1  Sunderland Pharmacy School, University of Sunderland, Wharncliffe Street, Sunderland, SR1 3SD, UK

Abstract: 5-BromoVerongamine has been successfully synthesized in 2 steps in good yield from readily available starting materials. Structural elucidation has been confirmed through direct comparison with spectroscopic data of isolated natural product. 5-BromoVerongamine has been shown to have moderate bacteriacidal activity against MRSA.
Keywords: marine sponge metabolites, bromotyramine, bromotyrosine, anti-bacterials
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