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Synthesis of Optically Active n-Alkyloxycatechols as Inhibitors of Lipoxygenase
Published: 01 September 1997 by MDPI in The 1st International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis
Abstract: Antioxidant activitv guided fractionation of extracts of Plectranthus sylvestris (labiatae) yielded the novel alkyloxycatechols 1-3 (M. Juch, P. Rüedi, Helv. Chim. Acta 1997, 80, 436). The optically active natural products and several diastereomers have been synthesized. The open chain compounds are prepared by enantioselsective reduction of the corresponding aldol adduct and chromatographic separation of the diastereomers, the cyclic ones by biomimetic phenol oxidation of 2b.