Introduction. An uncontrolled flow of migration and powerful anti-vaccination propaganda have led to an outbreak of vaccine-controlled infections among the Russian population in recent years.

The purpose of this study is to assess the dynamics of the incidence of whooping cough, measles, and rubella among the population in the Southern Federal District of the Russian Federation in the period of 2010 to 2023.

Methods. Thi study is based on data from the federal statistical observation form "Information on the number of diseases registered in patients living in the service area of a medical organization" for the period of 2015 to 2023.

Results. Between 2010 and 2023, the number of whooping cough cases amounted to 9199. The lowest number of whooping cough cases in the Southern Federal District was registered in 2021 and amounted to 15 (0.16%). The largest number of whooping cough cases was registered in 2023 and amounted to 4511 (49.04% of all detected cases since 2010). Krasnodar had the highest number of cases (2027—24.7%), followed by Rostov in second place (635 cases—6.9%) and Volgograd in third place (473 cases—5.14%).

The number of cases of rubella in the period from 2010 to 2023 in the Southern Federal District amounted to 108. The smallest number of cases was 0, and this was registered in the period from 2017 to 2023. The largest number was 30 cases, and thiswas registered in 2013 (27.78% of all detected cases since 2010). In first place for the number of cases of rubella was Krasnodar (23 cases—21.3%) in 2013, in second place was Volgograd (13 cases—12.04%) in 2010, and in third place was Astrakhan (12 cases—11.11%) in 2014.

Conclusions. During the studied period, the largest number of cases of whooping cough and rubella was registered in the Krasnodar region. The lowest number of cases of all nosologies was registered in 2020--2021, which was probably due to social isolation during the COVID-19 pandemic.