Optimization of Urea Formation with Phoxime™ Resin using the Nautilus™ 2400

Mark Scialdone; Steven Shuey; Alasdair MacDonald; William Newcomb; John Porco, Jr

doi:10.3390/ecsoc-1-02052

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Trapping of Nucleophiles by Rink Resin

Optimization of Urea Formation with Phoxime™ Resin using the Nautilus™ 2400

Mark A. Scialdone

¹,

Steven W. Shuey

¹,

Alasdair A. MacDonald

^{*

2},

William S. Newcomb

²,

John A. Porco, Jr

¹ DuPont Central R&D, Wilmington, DE. USA
² Argonaut Technologies, San Carlos, CA, USA

Published: 01 September 1997 by MDPI in The 1st International Electronic Conference on Synthetic Organic Chemistry session Combinatorial Synthesis and Automation

https://doi.org/10.3390/ecsoc-1-02052

Abstract: Phosgenated p-nitrophenyl(polystyrene)ketoxime (Phoxime™) resin (1) has been previously utilized as a latent isocyanate equivalent. The Nautilus™ 2400 automated organic synthesizer was used to determine the optimal temperature for thermolysis of the polymer-bound oxime-carbamate derived from Phoxime resin and subsequent amine addition to give a urea in solution.

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Mark Scialdone

Steven Shuey

Alasdair MacDonald

William Newcomb

John Porco, Jr