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Optimization of Urea Formation with Phoxime™ Resin using the Nautilus™ 2400
Published: 01 September 1997 by MDPI in The 1st International Electronic Conference on Synthetic Organic Chemistry session Combinatorial Synthesis and Automation
Abstract: Phosgenated p-nitrophenyl(polystyrene)ketoxime (Phoxime™) resin (1) has been previously utilized as a latent isocyanate equivalent. The Nautilus™ 2400 automated organic synthesizer was used to determine the optimal temperature for thermolysis of the polymer-bound oxime-carbamate derived from Phoxime resin and subsequent amine addition to give a urea in solution.