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A Novel Selective Synthesis of β-Isothiocyanato Ketones
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1  Department of Organic Chemistry, Moscow State University of Fine Chemical Technologies, Moscow, Russian Federation

Abstract: A new selective two-step synthesis of β-isothiocyanato ketones from α,β-unsaturated ketones has been developed. This synthesis includes preparation of β-azidoketones with subsequent reaction of these with triphenylphosphine and carbon disulfide. This approach is especially useful for synthesis of β-unsubstituted β-isothiocyanato ketones, which are impossible to prepare with sufficient purity via commonly used procedures.
Keywords: Azides; Isothiocyanates; Carbonyl Compounds; Phosphorus Compounds; Three-component Reaction