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Enantioselective Synthesis of 3-Substituted Isoindolinones via Chiral Phase-Transfer Catalyzed Intramolecular Aza-Michael Reactions
Published: 31 October 2013 by MDPI in The 17th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis
Abstract: Optically active isoindolinones are synthesized by asymmetric intramolecular aza-Michael reactions using cinchoninium phase-transfer organocatalysts. The resulting compounds are useful intermediates for the synthesis and development of benzodiazepine-receptor agonists.
Keywords: organocatalysis, phase-transfer catalysis, aza-Michael, heterocycle, isoindolinone.