Enantioselective Synthesis of 3-Substituted Isoindolinones via Chiral Phase-Transfer Catalyzed Intramolecular Aza-Michael Reactions

Eric Deniau; Stéphane Lebrun

doi:10.3390/ecsoc-17-a033

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Enantioselective Synthesis of 3-Substituted Isoindolinones via Chiral Phase-Transfer Catalyzed Intramolecular Aza-Michael Reactions

Eric Deniau

^*,

Stéphane Lebrun

¹ LCOP, EA CMF 4478

Published: 31 October 2013 by MDPI in The 17th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-17-a033

Abstract: Optically active isoindolinones are synthesized by asymmetric intramolecular aza-Michael reactions using cinchoninium phase-transfer organocatalysts. The resulting compounds are useful intermediates for the synthesis and development of benzodiazepine-receptor agonists.

Keywords: organocatalysis, phase-transfer catalysis, aza-Michael, heterocycle, isoindolinone.

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Eric Deniau

Stéphane Lebrun