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Enantioselective Synthesis of 3-Substituted Isoindolinones via Chiral Phase-Transfer Catalyzed Intramolecular Aza-Michael Reactions
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1  LCOP, EA CMF 4478

Abstract: Optically active isoindolinones are synthesized by asymmetric intramolecular aza-Michael reactions using cinchoninium phase-transfer organocatalysts. The resulting compounds are useful intermediates for the synthesis and development of benzodiazepine-receptor agonists.
Keywords: organocatalysis, phase-transfer catalysis, aza-Michael, heterocycle, isoindolinone.