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Nitrogen Heterocycles as Potential Antibacterial Agents
1 , 1 , 2 , 1 , 1 , * 1 , 1 , 3 , 1
1  Laboratorio de Síntesis Orgánica, Universidad de Talca, Chile
2  Vicerrectoría de Investigación y Estudios Avanzados, Pontificia Universidad Católica De Valparaíso.
3  Laboratorio de Bio-Organica, Instituto de Ciencias Quimicas, Facultad de Ciencias, Universidad Austral de Chile, Casilla 567, Valdivia, Chile.

Abstract: Nitrogen heterocycles are a part of a special group of organic substances due to its many applications in the pharmaceutical market, exist a large number of structures carrying nitrogenous substances. Among these heterocycles the isoxazoles and tetrahydroquinolines (THQs)1 have shown significant biological activity on different therapeutic targets. They show several applications in diverse areas such as pharmaceuticals, agrochemistry, and industry.2 They are also found in natural sources showing insecticidal, plant growth regulation, and pigment functions.3 Within the field of activity of the heterocycles is found the antibacterial activity, which has had a growing interest because the inappropriated use of antibiotic has increased the resistance of bacterial to the commercial antibiotics, even the appearance of bacterial strain with no treatment knows.4 Similarly, the emergence of antibiotic resistance in some bacterial populations is yet a relevant field of study in some areas of Science included the organic chemistry.Due to mentioned previously, the THQs e isoxazole compounds have been considered a good starting material for the search of novel antimicrobial agents, therefore we include them in this research.Isoxazoles derivatives were synthesized by 1,3 dipolar cycloaddition and a serie of tetrahydroquinolines derivatives were synthesized by Povarov reaction, these compounds were purified by conventional chromatographic techniques and characterized spectroscopically. Antibacterial activity was assessed by spectrophotometric measurements, determining the MIC for each compound against the four bacterial, Escherichia coli, Pseudomona aeruginosa, Staphylococcus aureus and Acinetobacter baumannii.
Keywords: Tetrahydroquinolines; isoxazoles, antibacterial activity
Comments on this paper
David Mauricio Ramírez Sánchez
Tetrahydroquinolines as antibacterial agents
It is a very good idea to use the nitrogen compounds as antibacterial
agents, but, currently does it exist background about pharmacological
evaluation and clinical studies supporting or demonstrating that

compounds inclusion as tetrahydroquinolines can help to the
rational use of antibiotics?.
I think this is an interesting fact, because it includes new molecules
that could help in dealing with problems as resistance to existing