Nickel-based alloys, including Inconel 718 and alloy 625, are indispensable in industries such as aerospace, marine, and nuclear energy due to their exceptional mechanical strength, high-temperature performance, and corrosion resistance. Despite their advantages, these alloys present significant challenges during machining owing to their hardness, and low thermal conductivity. To address these issues, advancements in tool coatings and materials have become critical, driving innovation in machining technologies. Coatings such as Titanium Aluminum Nitride (TiAlN) and Titanium Silicon Nitride (TiSiN) are recognized for their high thermal stability, hardness, and oxidation resistance, making them ideal for high-speed and elevated-temperature machining. Nano-Composite Coating (nACo) provides enhanced wear resistance, while Titanium Nitride (TiN) and Titanium Carbonitride (TiCN) offer anti-friction properties and toughness, respectively. Aluminum Oxide (Al₂O₃) delivers superior thermal stability and resistance to abrasive wear. Advanced solutions include multilayer coatings like TiAlN/TiN, which combine thermal resistance and toughness, and doped Ti₃AlN coatings enhanced with chromium or vanadium to improve hardness and machining efficiency. Tool materials have also seen significant advancements. Cemented carbides remain widely used due to their balance of hardness and toughness, while ceramic tools offer exceptional thermal stability for high-speed operations. Polycrystalline Cubic Boron Nitride (PCBN) excels in machining hardened alloys, and Polycrystalline Diamond (PCD) extends tool life significantly, particularly in milling applications. Nanoscale structured tools, often combined with optimized coatings, provide enhanced cutting efficiency. Tool wear caused by the hardness and work-hardening nature of nickel-based alloys necessitates robust coatings like TiAlN and multilayer systems to maintain thermal and mechanical stability. The integration of innovative coatings and tool materials has significantly improved the machinability of nickel-based alloys. Technologies such as TiAlN, TiSiN, and advanced multilayer systems, coupled with cutting-edge materials like PCD, continue to enhance wear resistance, reduce cutting forces, and ensure superior surface integrity.