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Preparation of Risedronate Nanoparticles Using Selected Polymeric Excipients
1 , 2 , 3 , * 1, 4
1  Department of Analytical Chemistry, Faculty of Natural Sciences, Comenius University, Ilkovicova 6, 84215 Bratislava, Slovakia
2  Nanotechnology Centre, VSB – Technical University of Ostrava, 17. listopadu 15/2172, 708 33 Ostrava – Poruba, Czech Republic
3  Faculty of Pharmacy, Komensky University, Ulica Odbojarov 10, 832 32, Bratislava 3, Slovakia
4  Institute of Neuroimmunology, Slovak Academy of Sciences, Dubravska Cesta 9, 845 10 Bratislava, Slovakia

Abstract: Almost all newly designed drugs (new chemical entities) demonstrate problematic aqueous solubility and/or permeability through biological membranes, i.e. they show poor bioavailability. One of the progressive ways for increasing bioavaibility is a technique of nanoparticles preparation, which allows many drugs to reach the site of action. Risedronate sodium (Biopharmaceutical Classification System class III) was chosen as a model compound with high solubility and low permeability. Nanoparticles of risedronate sodium are stabilized by polyethylene glycol or sodium carboxymethyl dextran. All prepared samples were measured by dynamic light scattering, and it was found that the particle size ranged from 2.8 to 9.1 nm.
Keywords: Risedronate; Bisphosphonates; Nanoparticles; Polymeric excipients; Dynamic light scattering.