Please login first
Events About
Contact
My Submissions
Synthesis and Reactions of Pyrazolo[5,1-c][1,2,4]triazine-3-Carbothioamides
Irina Ledeneva
* 1 ,
Vitaly Didenko
1 ,
Victor V. Dotsenko
2, 3, 4 ,
Khidmet Shikhaliev
1
1  Voronezh State University, 1 Universitetskaya pl., 394006 Voronezh, Russia
2  Kuban State University, 149 Stavropolskaya Str., Krasnodar 350040, Russian Federation
3  ChemEx Lab, Vladimir Dal’ Lugansk National University, Lugansk, 91034 Russia.
4  North-Caucasus Federal University, 1 Pushkina St., 355009 Stavropol, Russian Federation
Published: 31 October 2013 by MDPI in The 17th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis
https://doi.org/10.3390/ecsoc-17-a040
Abstract: Cyanothioacetamide reacts with pyrazole-3(5)-diazonium chlorides under mild conditions to afford pyrazolo[5,1-c][1,2,4]triazine-3-carbothioamides. The latter can be oxidized with H2O2 to give either pyrazolo[5,1-c][1,2,4]triazine-3-carboxamides or 1,2,4-thiadiazole derivatives, depending on the reaction conditions. The Hantzsch-type reaction of thioamides 5 with α-bromo ketones leads to 3-(thiazol-2-yl)pyrazolo[5,1-c][1,2,4]triazines.
Keywords: Azo-coupling, Cyanothioacetamide, Hantzsch thiazole synthesis, Heterocyclization, Pyrazole-3(5)-diazonium salts, Pyrazolo[5,1-c][1,2,4]triazines, Oxidation of thioamides
View paper
  • Open Access
  • 74 Reads
  • 0 Recommendations
Comments on this paper
Christian Ogden
8 June 2018
education
When I visit this page then I came to know about the so many different topics and also recommend you this page to join and collect information. In all countries there are so many https://www.topdissertations.org/dissertationteam-review/ that are the best working in all over the world.
Christian Ogden
8 June 2018
education
When I visit this page then I came to know about the so many different topics and also recommend you this page to join and collect information. In all countries there are so many https://www.topdissertations.org/dissertationteam-review/ that are the best working in all over the world.


 
 
Top