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Synthesis and Characterization of Tetrahydroquinolines as Acetylcholinesterase Inhibitors
* 1 , 1 , 1 , 2 , 3 , 4 , 1
1  Laboratorio de Síntesis Orgánica, Universidad de Talca, Chile
2  Vicerrectoría de Investigación y Estudios Avanzados, Pontificia Universidad Católica De Valparaíso.
3  Laboratorio de Bio-Organica, Instituto de Ciencias Quimicas, Facultad de Ciencias, Universidad Austral de Chile, Casilla 567, Valdivia, Chile.
4  CIC nanoGUNE, Tolosa Hiribidea 76, 20018 Donostia-San Sebastian, Spaña.

Abstract: Quinoline is a heterocyclic scaffold of paramount importance to human race. Quinolines and their derivatives occur in numerous natural resources. Compounds containing quinoline structure are widely used as antiasthmatic, antimalarials, anti-viral, anti-inflammatory, antibacterials, antifungals, and anticancer (1). Among quinoline derivatives, tetrahydroquinolines (THQs) are an important structural subunit of natural and synthetic products and many THQs derivatives exhibit interesting biological and pharmaceutical activities (2). Many quinoline derivatives have shown anti-cholinesterase activity and can be potential agents for treatment of Alzheimer disease (3-5).In the present study we have synthesized 7 derivatives of THQs with different patterns of substituent using the Povarov reaction in presence of Lewis acid, all compounds was characterized by 1H-NMR, 13C-NMR and Mass Spectra, and evaluated as potentials inhibitors of acetylcholinesterase.
Keywords: Tetrahydroquinolines, Acetylcholinesterase, Povarov Reaction
Comments on this paper
David Mauricio Ramírez Sánchez
Acetylcholinesterase inhibitors
Quinolines and tetrahydroquinolines compounds are very important
and they have a lot of pharmaceutical applications. They are also  
widely used as medicines to treat many pathologies. 
I think it is very useful to incorporate this kind of molecules in the
acetylcholinesterase inhibitors line because they can be potential
agents for the treatment of Alzheimer disease. 
Further studies that allow to understand more about this
agents are worth to do.