Antibiotic resistance is an escalating global public health issue that requires innovative strategies for reduction. Virtual reality (VR) is being utilised as a cutting-edge technology for medical training, patient education, and drug development. In this study, we aimed to review the role of VR in combating antibiotic-resistant infections by improving antibiotic administration, infection control methods, and surgical plans for resistant infections. VR-based simulations provide medical professionals with authentic training environments to improve their clinical decision-making and avoid antibiotic abuse. VR-inspired health-tech helps model bacterial resistance and new drug candidates, optimizing the antibiotic detection process. The combination of virtual reality (VR) with artificial intelligence (AI) and big data analytics enables real-time diagnosis, personalized treatment planning, and precision medicine. Additionally, using VR in public health initiatives improves patients' compliance with infection control measures. It has great potential but also drawbacks, such as high cost, availability issues, and the need to validate interventions affected by VR. The current review provides a perspective on the latest advances, challenges, and future methods for the implementation of VR in the treatment of infectious diseases. The use of VR can change the way in which we fight antibiotic resistance and pave the way for improved and more sustainable health solutions around the world.