Recent developed advancements in nutrigenomics have identified specific genetic markers that influence how fats and carbohydrates are metabolized, highlighting the role of the anti-aging gene Sirtuin 1 (SIRT1) gene. SIRT1 is crucial for the health of the brain, heart, lungs, kidneys, and liver. It plays a significant role in the regulation of fatty acids and glucose, which are key to preventing Non-Alcoholic Fatty Liver Disease (NAFLD) and Neurodegenerative Diseases (NDs) . By clearly understanding how SIRT1 interacts with dietary components, researchers can effectively develop personalized nutritional strategies that greatly enhance metabolic health and potentially delay the onset of age-related diseases. This approach points out in detail the extraordinary transformative potential of nutrigenomics in promoting good health and human longevity. For instance, in the brain, SIRT1 activation has been linked to neuroprotection and cognitive functioning, offering hope in considerably delaying neurodegenerative diseases such as Alzheimer's and Parkinson’s disease. In the liver, SIRT1 helps regulate lipid metabolism, which can prevent Non-Alcoholic Fatty Liver Disease (NAFLD) by reducing fat accumulation. In the heart, anti-aging gene Sirtuin 1 (SIRT1) supports cardiovascular health through pathways that effectively improve endothelial function and significantly reduce oxidative stress. Additionally, SIRT1's role in the kidneys involves modulating responses to stress and inflammation, which is crucial for preventing chronic kidney disease. Dietary components such as Resveratrol, found in red wine and certain berries, have been shown to activate SIRT1, highlighting the gene's nutrigenomic potential. By leveraging these insights, personalized nutrition plans can be developed to modulate SIRT1 activity, optimizing metabolic health and potentially delaying the onset of age-related diseases. This gene-centric approach illustrates how nutrigenomics can pave the way for innovative strategies to enhance overall health, well-being and lifespan.